Publikationen

Publikationen 2021

  • Manda K, Juerß D, Fischer P, Schröder A, Koenen A, Hildebrandt G. Simvastatin treatment varies the radiation response of human breast cells in 2D or 3D culture. Invest New Drugs. (2021); DOI: 10.1007/s10637-020-01046-6. PMID: 33313978.

Publikationen 2020

  • Manda K, Kriesen S, Hildebrandt G. The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues.Medical oncology (2020); DOI: 10.1007/s12032-020-01437-y. PMID:33205219.
  • Manda K, Präkelt T, Baumgart T, Hildebrandt G. Radiosensitizing effect of trabectedin on human A549 lung and HT-29 colon cancer cells. Invest. New Drugs (2020); 38(4): 967–976. PMID:31482373.
  • Käsmann L, Schröder A, Frey B, Fleischmann DF, Gauer T, Ebert N,  Hecht M, Krug D, Niyazi M, Mäurer M. Peer review analysis in the field of radiation oncology: results from a web-based survey of the Young DEGRO working group. Strahlenther Onkol (2020). doi.org/10.1007/s00066-020-01729-2. PMID: 33337507.

Publikationen 2019

  • Schröder A, Kriesen S, Hildebrandt G, Manda K. First insights into the effect of low-dose X-ray irradiation in adipose-derived stem cells; Int. J. Mol. Sci. (2019), 20, 6075; doi:10.3390/ijms20236075. PMID:31810198.
  • Schröder S, Broese S, Baake J, Juerß D, Kriesen S, Hildebrandt G, Manda K. Effect of ionizing radiation on human EA.hy926 endothelial cells under inflammatory conditions and their interactions with A549 tumour cells. J Immunol. Res. (2019); doi.org/10.1155/2019/9645481. PMID:31565662.
  • Schröder S, Juerß D, Kriesen S, Manda K, Hildebrandt G. Immunomodulatory properties of low-dose ionizing radiation on human endothelial cells. Int J Radiat Biol. (2019); doi:10.1080/09553002.2018.1486515. PMID:29883248.

Publikationen 2018

  • Baaße A, Machoy F, Juerß D, Baake J, Stang F, Reimer T, Krapohl BD, Hildebrandt G. Radiation Sensitivity of Adipose-Derived Stem Cells Isolated from Breast Tissue. Int J Mol Sci. (2018); doi:10.3390/ijms19071988. PMID:29986519.
  • Schröder S, Kriesen S, Paape D, Hildebrandt G, Manda K. Modulation of inflammatory reactions by low dose ionizing radiation: cytokine release of murine endothelial cells is dependent on culture conditions. J Immunol Res. (2018); doi.org/10.1155/2018/2856518.
  • Baaße A, Reape E, Juerß D, Manda K, Hildebrandt G. Promoting effects of adipose-derived stem cells on breast cancer cells are reversed by radiation therapy. Cytotechnology 70(2):701-711 (2018). PMID:29188405.
  • Schültke E, Bräuer-Krisch E, Blattmann H, Requardt H, Laissue JA, Hildebrandt G. Survival of rats bearing advanced intracerebral F 98 tumors after glutathione depletion and microbeam radiation therapy: conclusions from a pilot project.Radiat Oncol. (2018); doi:10.1186/s13014-018-1038-6. PMID:29747666.
  • Smith R, Wang J, Seymour C, Fernandez-Palomo C, Fazzari J, Schültke E, Bräuer-Krisch E, Laissue J, Schroll C, Mothersill C. Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats.Dose Response (2018);  doi:10.1177/1559325817750068. PMID:29383012.

Publikationen 2017

  • Juerß D, Zwar M, Giesen U, Nolte R, Kriesen S, Baiocco G, Puchalska M, van Goethem MJ, Manda K, Hildebrandt G. Comparative study of the influence of different radiation qualities on normal human breast cells. Rad Oncol. (2017) doi: 10.1186/s13014-017-0895-8. PMID:28946898.
  • Schültke E, Balosso J, Breslin T, Cavaletti G, Djonov V, Esteve F, Grotzer M, Hildebrandt G, Valdman A, Laissue JA. Microbeam radiation therapy: grid therapy and beyond. A clinical perspective. Br J Radiol. (2017); doi:10.1259/bjr.20170073. PMID:28749174.

Publikationen 2016

  • Fernandez-Palomo C, Schültke E, Bräuer-Krisch E, Laissue JA, Blattmann H, Seymour C, Mothersill C. Investigation of Abscopal and Bystander Effects in Immunocompromised Mice After Exposure to Pencilbeam and Microbeam Synchrotron Radiation. Health Phys.; 111(2):149-59. (2016). PMID:27356059.
  • Mathias D, Mitchel RE, Barclay M, Wyatt H, Bugden M, Priest ND, Whitman SC, Scholz M, Hildebrandt G, Kamprad M, Glasow A. Correction: Low-Dose Irradiation Affects Expression of Inflammatory Markers in the Heart of ApoE -/- Mice. PLoS One. ; 11(6) (2016). PMID:27280530 (Erratum for PMID:25799423).

Publikationen 2015

  • Baumgart T, Kriesen S, Neels O, Hildebrandt G, Manda K. Investigation of epothilone B-induced cell death mechanisms in human epithelial cancer cells – in consideration of combined treatment with ionising radiation. Cancer Invest. 33(6):213-224 (2015). PMID: 25919223.
  • Mathias D, Mitchel RE, Barclay M, Wyatt H, Bugden M, Priest ND, Whitman SC, Scholz M, Hildebrandt G, Kamprad M, Glasow A. Low-dose irradiation affects expression of inflammatory markers in the heart of ApoE-/- mice. PLoS One. (2015); doi:10.1371/journal.pone.0119661. PMID:25799423.
  • Patties I, Haagen J, Dörr W, Hildebrandt G, Glasow A. Late inflammatory and thrombotic changes in irradiated hearts of C57BL/6 wild-type and atherosclerosis-prone ApoE-deficient mice.Strahlenther Onkol 191(2):172-179 (2015). PMID:25200359.
  • Fernandez-Palomo C, Mothersill C, Bräuer-Krisch E, Laissue J, Seymour C, Schültke E. γ-H2AX as a marker for dose deposition in the brain of wistar rats after synchrotron microbeam radiation. PLoS One. 23; 10(3) (2015). PMID:25799425.

Publikationen 2014

  • Haustein M, Ramer R, Linnebacher M, Manda K, Hinz B. Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochem Pharmacol 92(2):312-325 (2014). PMID:25069049.
  • Ramer R, Fischer S, Haustein M, Manda K, Hinz B. Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells.Biochem Pharmacol. 91:202-216 (2014). PMID:24976505.
  • Manda K, Kavanagh JN, Buttler D, Prise KM, Hildebrandt G. Low dose effects of ionizing radiation on normal tissue stem cells. Mutat Res-Rev Mutat. 761:6-14 (2014). PMID:24566131.
  • Acheva A, Aerts A, Rombouts C, Baatout S, Salomaa S, Manda K, Hildebrandt G, Kämäräinen M. Human 3-D tissue models in radiation biology: current status and future perspective. Int J Radiat Res. 12(2):81-98 (2014).
  • Patties I, Habelt B, Rosin B, Dörr W, Hildebrandt G, Glasow A. Late effects of local irradiation on the expression of inflammatory markers in the Arteria saphena of C57BL/6 wild-type and ApoE-knockout mice.Radiat Environ Biophys. 53(1):117-24 (2014). PMID:24071970.

Publikationen 2013

  • Jaeger A, Baake J, Weiss DG, Kriehuber R. Glycogen synthase kinase-3beta regulates differentiation-induced apoptosis of human neural progenitor cells.Int J Dev Neurosci. 31(1):61-8 (2013). PMID:23085082.
  • Mitchel RE, Hasu M, Bugden M, Wyatt H, Hildebrandt G, Chen YX, Priest ND, Whitman SC. Low-dose radiation exposure and protection against atherosclerosis in ApoE(-/-) mice: the influence of p53 heterozygosity.Radiat Res. 179(2):190-9 (2013). PMID:23289388.
  • Kadhim M, Salomaa S, Wright E, Hildebrandt G, Belyakov OV, Prise KM, Little MP. Non-targeted effects of ionising radiation-Implications for low dose risk.Mutat Res. 752(2):84-98 (2013). PMID:23262375.
  • Buttler D, Mai JK, Ashwell KW, Andressen C. Clonogenic CD15 immunoreactive radial glial cells from the developing human lateral ganglionic eminence.Curr Pharm Biotechnol. 14(1):29-35 (2013). PMID: 23092258.

Publikationen 2012

  • Rödel F#, Frey B#, Manda K, Hildebrandt G, Hehlgans S, Keilholz L, Seegenschmiedt MH, Gaipl US and Rödel C. Immunomodulatory properties and molecular effects in inflammatory diseases of low-dose X-irradiation.Frontiers in Molecular and Cellular Oncology (2012); DOI: 10.3389/fonc.2012.00120. (# both authors have contributed equally to this work). PMID:23057008.
  • Manda K#, Glasow A#, Paape D, Hildebrandt G. Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic cells and T cells.Frontiers in Molecular and Cellular Oncology. (2012); DOI: 10.3389/fonc.2012.00102. (# both authors have contributed equally to this work). PMID:22937525.
  • Baumgart T, Kriesen S, Hildebrandt G, Manda K. Effect of epothilone B on cell cycle, metabolic activity, and apoptosis induction on human epithelial cancer cells - under special attention of combined treatment with ionizing radiation. Cancer Invest. 30(8):593-603 (2012). PMID:22909073.
  • Rödel F, Frey B, Gaipl U, Keilholz L, Fournier C, Manda K, Schöllnberger H, Hildebrandt G,  Rödel C. Modulation of Inflammatory Immune Reactions by Low-Dose Ionizing Radiation: Molecular Mechanisms and Clinical Application. Curr Med Chem. 19:1741-1750 (2012). PMID:22414082.
  • Baumgart T, Klautke G, Kriesen S, Kuznetsov S, Weiss DG, Fietkau R, Hildebrandt G, Manda K. Radiosensitizing effect of epothilone B on human epithelial cancer cells.Strahlenther Onkol. 188(2):177-184 (2012). PMID:22234539.
  • Tiemann N, Hildebrandt G, Manda K. Unexpected effect of the monoclonal antibody Panitumumab on human cancer cells with different KRAS status.Med Oncol. 29(3):2276-2283 (2012). PMID:21842425.

Publikationen 2011

  • Jahns J, Anderegg U, Saalbach A, Rosin B, Patties I, Glasow A, Kamprad M, Scholz M, Hildebrandt G. Influence of low dose irradiation on differentiation, maturation and T-cell activation of human dendritic cells.Mutat Res. 709-710:32-39 (2011). PMID:21376737.
  • Mitchel, REJ, Hasu M, Bugden M, Wyatt H, Little M, Hildebrandt G, Priest ND, Whitman SC. Low Dose Radiation Exposure and Atherosclerosis in ApoE-/- Mice.Radiat Res. 175(5):665-676 (2011). PMID:21375359.
  • Manda K, Kriesen S, Hildebrandt G, Fietkau R, Klautke G. Omega-3 fatty acid supplementation in cancer therapy: does Eicosapentaenoic acid influence the radiosensitivity of tumor cells?Strahlenther Onkol. 187(2):127-134 (2011). PMID:21267532.

Publikationen 2010

  • Bogdándi EN, Balogh A, Felgyinszky N, Szatmári T, Persa E, Hildebrandt G, Sáfrány G, Lumniczky K. Low dose radiation effects on the immune system of mice after total body irradiation.Radiat Res. 174(4):480-489 (2010). PMID:20726712.
  • Rödel F, Frey B, Capalbo G, Gaipl U, Keilholz L, Voll R, Hildebrandt G, Rödel C. Discontinuous induction of X-linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-kappaB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation.Radiother Oncol. 97:346-351 (2010). PMID:20170972.
  • Hildebrandt G. Non-cancer diseases and non-targeted effects.Mutat Res. 687(1-2):73-77 (2010). PMID:20097211.
  • Jacquet P, Buset J, Neefs M, Vankerkom J, Benotmane MA, Derradji H,  Hildebrandt G, Baatout S. Transgenerational developmental effects and genomic instability after X-irradiation of preimplantation embryos: studies on two mouse strains. Mutat Res. 687(1-2):54-62 (2010). PMID:20096709.
  • Salomaa S, Wright E,  Hildebrandt G, Kadhim M, Little M, Prise K, Belyakov OV.: Editorial to Mutation research special issue.Mutat Res. 687(1-2):1-2 (2010). PMID:20100499.
  • Little, MP, Tawn, EJ, Tzoulaki, I, Wakeford, R, Hildebrandt, G, Paris, F, Tapio, S, Elliott, P: Review and meta-analysis of epidemiological associations between low and moderate doses of ionizing radiation and late circulatory disease risks, and their possible mechanisms. Radiat Environ Biophys. 49(2):139-153 (2010). PMID: 19862545

Publikationen 2009

  • Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Tapio S: Comments: The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946–2005.Int J Epidemiol. 38(4):1159-1164 (2009). PM:18614611.
  • Patties I, Jahns J, Hildebrandt G, Kortmann RD, Glasow A: Additive effects of 5’Aza-2’deoxycytidine and irradiation on clonogenic survival of human medullo-blastoma cell lines.Strahlenther Onkol. 185(5):331-338 (2009). PM:19440673.
  • Fricke, S, Ackermann, M, Stolzing, A, Hilger, N, Schimmelpfennig, C, Jahns, J, Hildebrandt, G, Emmrich, F, Boltze, J, Kamprad, M, Sack, U: Allogeneic nonadherent stem cells facilitate hematopoietic recovery but do not lead to allogeneic engraftment.PLoS One. 4(7):e6157 (2009). PM:19582154.

Publikationen 2008 und früher

  • Little MP, Tawn EJ, Tzoulaki I, Wakeford R, Hildebrandt G, Paris F, Tapio S, Elliott P: A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms.Radiat Res. 169:99-109 (2008). PM:18159955.
  • Glasow A, Barrett A, Petrie K, Gupta R, Boix-Chornet M, Zhou DC, Grimwade D, Gallagher R, von Lindern M, Waxmann S, Enver T, Hildebrandt G, Zelent A: DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia.Blood 111(4):2374-2377 (2008). PM:17993618.
  • Rödel F, Keilholz L, Herrmann M, Sauer R, Hildebrandt G: Radiobiological mechanisms in inflammatory diseases of low dose radiation therapy.Int J Radiat Biol 83(6):357-366 (2007). PM:17487675.
  • Leo C, Horn LC, Rauscher C, Hentschel B, Liebmann A, Hildebrandt G. Höckel M: Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis.Clin Cancer Res. 12(23):6894-6900 (2006). PM:17145806.
  • Rödel F, Franz S, Sheriff A, Gaipl U, Heyder P, Hildebrandt G, Voll RE, Herrmann M: The CFSE distribution assay is a powerful technique for the analysis of radiation induced cell death and survival on a single cell level. Strahlenther Onkol. 181(7):456-462 (2005). PM:15995839.
  • Schaue D, Jahns J, Hildebrandt G, Trott KR: Radiation treatment of acute inflam-mation in mice.Int J Radiat Biol. 81:657-667 (2005). PM:16368644.
  • Rödel F, Hantschel M, Hildebrandt G, Schultze-Mosgau S, Rödel C, Herrmann M, Sauer R, Voll RE: Dose dependent biphasic induction and transcriptional activity of nuclear factor kappa B (NF-kB) in EA.hy.926 endothelial cells after low‑dose X-irradiation. Int J Radiat Biol. 80:115-123 (2004). PM:15164793.
  • Liebmann A, Hindemith M, Jahns J, Madaj-Sterba P, Weisheit S, Kamprad F, Hildebrandt G: Low dose X-irradiation of adjuvant induced arthritis in rats – Efficacy of different fractionation schedules. Strahlenther Onkol. 180:165-172 (2004). PM:14991205.
  • Rödel F, Schaller U, Schultze-Mosgau S, Beuscher HU, Keilholz L, Herrmann M, Voll R, Sauer R, Hildebrandt G: The induction of TGF-ß1 and NF-kB parallels a biphasic time course of leukocyte / endothelial cell adhesion following low-dose X-irradiation. Strahlenther Onkol. 180:194-200 (2004). PM:15057429.
  • Hildebrandt G, Loppnow G, Jahns J, Hindemith M, Anderegg U, Saalbach A, Kamprad F: Inhibition of the iNOS-pathway in inflammatory macrophages by low dose X-irradiation – Is there a time dependence?Strahlenther Onkol. 179:158-166 (2003). PM:12627258.
  • Hildebrandt G, Radlingmayr A, Rosenthal S, Rothe R, Jahns J, Hindemith M, Kamprad F: Low-dose radiotherapy (LD-RT) and the modulation of iNOS-expression in adjuvant arthritis in rats. Int J Radiat Biol. 79:993-1001 (2003). PM:14713577.
  • Österreicher J, Škopek J, Jahns J, Hildebrandt G, Psutka J, Vilasová Z, Tanner JM, Vogt J, Butz T (2003): b1-integrin and IL-1a expression as bystander effect of medium from irradiated cells: the pilot study. Acta Histochem. 105:223-230 (2003). PM:13677615.
  • Rödel F, Kamprad F, Sauer R, Hildebrandt G: Funktionelle und molekulare Aspekte der antiinflammatorischen Wirkung niedrig dosierter Radiotherapie.Strahlenther Onkol. 178:1-9 (2002). PM:11977385.
  • Gershkevitsh E, Hildebrandt G, Wolf U, Kamprad F, Realo E, Trott KR: Chromo-somal aberration in peripheral lymphocytes and doses to the active bone marrow in radiotherapy of prostate cancer.Strahlenther Onkol. 178:36-42 (2002). PM:11977390.
  • Hildebrandt G, Magiorella L, Rödel V, Rödel F, Willis D, Trott KR: Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in vitro. Int J Radiat Biol. 78:315-325 (2002). PM:12020443.
  • Wandel E, Raschke A, Hildebrandt G, Eberle J, Dummer R, Anderegg U, Saalbach A: Fibroblasts enhance the invasive capacity of melanoma cells in vitro. Arch Dermatol Res. 293:601-608 (2002). PM:11875642.
  • Anderegg U, Prieb J, Hildebrandt G, Saalbach A: Minocycline does not alter collagen type I metabolism of dermal fibroblasts in culture. Arch Dermatol Res. 294:103-108 (2002). PM:12029495.
  • Saalbach A, Hildebrandt G, Haustein UF, Anderegg U: The Thy1 / Thy-1-ligand-interaction is involved in binding of melanoma cells to activated Thy-1-positive microvascular endothelial cells. Microvascular Research 64:86-93 (2002). PM:12074634.
  • Rödel F, Kley N, Beuscher HU, Hildebrandt G, Keilholz L, Kern P, Voll R, Herrmann M, Sauer R: Anti-inflammatory effect of low dose X-irradiation and the involvement of a TGF-ß1-induced down-regulation of leucocyte / endothelial cell adhesion. Int J Radiat Biol. 78:711-719 (2002). PM:12194755.
  • Hildebrandt G, Jahns J, Hindemith M, Spranger S, Sack U, Kinne RW, Madaj-Sterba P, Wolf U, Kamprad F: Effects of low dose radiation therapy on adjuvant induced arthritis in rats. Int J Radiat Biol. 76:1143-1153 (2000). PM:10947127.
  • Hildebrandt G, Seed MP, Freemantle CN, Alam CAS, Colville-Nash PR, Trott KR: Mechanisms of the anti-inflammatory activity of low-dose radiation therapy.IntJ Radiat Biol. 74:367-378 (1998). PM:9737539.
  • Hildebrandt G, Seed MP, Freemantle CN, Alam CAS, Colville-Nash PR, Trott KR: Effects of low dose ionizing radiation on murine chronic granulomatous tissue. Strahlenther Onkol. 174:580-588 (1998). PM:9830440.
  • Fischer U, Kamprad F, Koch F, Ludewig E, Melzer R, Hildebrandt G: Effekte einer niedrig dosierten Co-60-Bestrahlung auf den Verlauf einer aseptischen Arthritis am Kniegelenk des Kaninchens.Strahlenther Onkol. 174:633-639 (1998). PM:9879351