Multidisciplinary European Low Dose Initiative (MELODI)

The purpose of MELODI is to coordinate and promote European research on the risks associated with low dose exposure to ionizing radiation.
MELODI is a research platform, in accordance with relevant European Union policies. In this context, it will contribute to the definition of priority objectives in low dose risk research, identification of research programs and resources to be implemented in order to achieve these objectives, assessment of results obtained, and promotion of communication on these issues between the various parties involved.


Multidisciplinary evaluation of the cancer risk from neutrons relative to photons using stem cells and the analysis of second malignant neoplasms following paediatric radiation therapy (ANDANTE)

The project investigates the relative risk of neutrons compared to photons for tumorigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutrons in vitro and analysed for early indicators of malignant transformations. The experimental irradiation setup will be fully characterised and modelled in order to compare predicted molecular damage with biological results, following controlled irradiation with either photons or neutrons. A corresponding predictive model of the relative risk of cancer induction from photons or neutrons following paediatric radiotherapy will be developed and tested on clinical data, as a proof of principle, leading to a proposal for a prospective epidemiological study to validate the relative risk of neutrons on humans.

Förderung durch:      EU (FP7- 295970)

Förderzeitraum:        01/2012-12/2015


Modulation of Inflammation by low and moderate dose ionizing Irradiation (ModInIR)

The main objective of the project is to analyse the immune modulatory properties of low and moderate radiation doses.

Förderung durch:      EU (FP7-249689)

Förderzeitraum:        07/2011-12/2015


Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below (EpiRadBio)

The project combines epidemiology and radiobiology. Key factors of radiation induced carcinogenesis such as genomic instability will be measured in cancer tissues and blood samples from members of different radio-epidemiological cohorts. Intercellular communication after exposure to low-dose radiation exposure and its influence on apoptosis, cell proliferation, differentiation and genomic instability will be explored with 2D cell cultures and 3D tissue models. This includes research on stem cells. The results of the radiobiological studies will be integrated in the development of models of carcinogenesis for evaluation of major epidemiological cohorts: Atomic Bomb Survivors, French-Swedish-Italian Thyroid Cancer Cohort, Mayak Worker Cohort, Swedish Haemangioma Cohort, UkrAm Cohort on thyroid cancer after the Chernobyl accident, and UK National Registry for Radiation Workers.

Förderung durch:      EU (FP7-269553)

Förderzeitraum:        04/2011-03/2015


Real-time-Untersuchung der Strahlensensibilität verschiedener Tumorzellen unter Einfluss von Natriumselenit

Förderung durch:      Forschungsfonds Mecklenburg-Vorpommern

Förderzeitraum:        01/2013 - 02/2015

Proinflammatorische Effekte ionisierender Strahlung im Niedrigdosisbereich auf Endothelzellen: Vergleich von 2D- und 3D-Zellkulturmodellen

Förderung durch:      FORUN-Programm der Medizinischen Fakultät der Universität Rostock

Förderzeitraum:        01/2012-12/2012

The mechanism of cardiovascular risks after low radiation doses (CARDIORISK)

The aim of this European collaborative research project is to elucidate the pathogenesis of early and late alterations in the microcirculation of the heart and of atherosclerotic lesions after exposure to low radiation doses. A major goal will be the investigation of early molecular, proinflammatory and prothrombotic changes as well as perfusion alteration, cardiac cell integrity and immunologic influences.

Förderung durch:      EU (FP7)

Förderzeitraum:        02/2007-06/2011


Non-targeted effects of ionising radiation (NOTE)

The project aims to expand the current understanding of health effects caused by low-level doses of ionising radiation. The key focus of the research programme is the possible health consequences of exposures to small radiation doses which have not been investigated sufficiently so far.

Förderung durch:      EU (FP6)Förderzeitraum:        09/2006-12/2010

Untersuchung des Einflusses der ungesättigten Omega-3 Fettsäure EPA (Eicosapentaenoic Acid) auf die Strahlensensibilität von verschiedenen Normalgewebs- und Tumorzellinien in vitro

Förderung durch:      Fresenius-Stiftung

Förderzeitraum:        10/2005-09/2007