Publikationen/Publications

Publikationen 2023

Schültke E, Pinzer BR, Stampanoni M, Harsan L, Döbrössy M. 3D Imaging of Striatal Transplants in a Small Animal Model of Huntington's Disease. Neurol Int. 2023 Jul 24;15(3):896-907. doi: 10.3390/neurolint15030057.
Breslin T, Paino J, Wegner M, Engels E, Fiedler S, Forrester H, Rennau H, Bustillo J, Cameron M, Häusermann D, Hall C, Krause D, Hildebrandt G, Lerch M, Schültke E. A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study. Biomimetics (Basel). 2023 May 31;8(2):230. doi: 10.3390/biomimetics8020230.
Jaekel F, Paino J, Engels E, Klein M, Barnes M, Häusermann D, Hall C, Zheng G, Wang H, Hildebrandt G, Lerch M, Schültke E. The Spinal Cord as Organ of Risk: Assessment for Acute and Subacute Neurological Adverse Effects after Microbeam Radiotherapy in a Rodent Model. Cancers (Basel). 2023 Apr 26;15(9):2470. doi: 10.3390/cancers15092470. PMID: 37173938 Free PMC article.

Publikationen 2022

Frerker B, Fiedler S, Kirschstein T, Lange F, Porath K, Sellmann T, Kutzner L, Wilde F, Moosmann J, Köhling R, Hildebrandt G, Schültke E. Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction. Cells. 2022;12(1):176. doi: 10.3390/cells12010176.
Schültke E, Jaekel F, Bartzsch S, Bräuer-Krisch E, Requardt H, Laissue JA, Blattmann H, Hildebrandt G. Good Timing Matters: The Spatially Fractionated High Dose Rate Boost Should Come First. Cancers (Basel). 2022;14(23):5964. doi: 10.3390/cancers14235964.
Schültke E, Fiedler S, Mewes C, Gargioni E, Klingenberg J, Abreu Faria G, Lerch M, Petasecca M, Prehn F, Wegner M, Scholz M, Jaekel F, Hildebrandt G. The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research. Cancers 2022, 14, 5137. doi.org/10.3390/ cancers14205137.
Al-Zeer MA, Prehn F, Fiedler S, Lienert U, Krisch M, Berg J, Kurreck J, Hildebrandt G, Schültke E. Evaluating the Suitability of 3D Bioprinted Samples for Experimental Radiotherapy: A Pilot Study. Int J Mol Sci. 2022 Sep 1;23(17):9951. doi: 10.3390/ijms23179951.PMID: 36077349.
Jaekel F, Bräuer-Krisch E, Bartzsch S, Laissue J, Blattmann H, Scholz M, Soloviova J, Hildebrandt G, Schültke E. Microbeam Irradiation as a Simultaneously Integrated Boost in a Conventional Whole-Brain Radiotherapy Protocol. Int J Mol Sci. 2022; 23(15):8319. doi: 10.3390/ijms23158319.PMID: 35955454.
Lange F, Kirschstein T, Davis J, Paino J, Barnes M, Klein M, Porath K, Stöhlmacher P, Fiedler S, Frank M, Köhling R, Hildebrandt G, Hausermann D, Lerch M, Schültke E. Microbeam irradiation of the beating rodent heart: an ex vivo study of acute and subacute effects on cardiac function. Int J Radiat Oncol Biol Phys. 2022 May 6:S0360-3016(22)00399-6. doi: 10.1016/j.ijrobp.2022.05.001. Online ahead of print. PMID: 35533907.
Schültke E, Lerch M, Kirschstein, Lange F, Porath K, Fiedler S, Davis J, Paino J, Engels E, Barnes M, Klein M, Hall C, Häusermann D, Hildebrandt G. Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at a synchrotron: 4000 Gy in a heart beat. J Synchroton Rad. July 2022, Volume 29, Part 4, doi.org/10.1107/S1600577522004489

Publikationen 2021

Schültke E, Fiedler S, Menk RH, Jaekel F, Dreossi D, Casarin K, Tromba G, Bartzsch S, Kriesen S, Hildebrandt G, Arfelli F. Perspectives for microbeam irradiation at the SYRMEP beamline. J Synchrotron Radiation, Volume 28, Part 2, pages 410-418. doi.org/10.1107/S1600577521000400

Publikationen 2020

Schültke E, Bayat S, Bartzsch S, Bräuer-Krisch E, Djonov V, Fiedler S, Fernandez-Palomo C, Jaekel F, Pellicioli P, Trappetti V, Hildebrandt G. A Mouse Model for Microbeam Radiation Therapy of the Lung. Int J Radiat Oncol Biol Phys. 2020 Dec 29:S0360-3016(20)34723-4. doi.org/10.1016/j.ijrobp.2020.12.030

Lange F, Hartung J, Liebelt C, Boisserée J, Resch T, Porath K, Hörnschemeyer J, Reichart G, Sellmann T, Neubert V, Kriesen S, Hildebrandt G, Schültke E, Köhling R, Kirschstein T. Perampanel Add-on to Standard Radiochemotherapy in vivo Promotes Neuroprotection in a Rodent F98 Glioma Model. Front Neurosci. 2020 Nov 30;14:598266. doi: 10.3389/fnins.2020.598266. eCollection 2020.PMID:33328869

Publikationen 2019

Coquery N, Adam JF, Nemoz C, Janvier R, Livingstone J, Chauvin A, Kefs S, Guerineau C, De Saint Jean L, Ocadiz A, Bouchet A, Bartzsch S, Schültke E, Siegbahn A, Bräuer-Krisch E, Lemasson B, Barbier EL, Laissue J, Balosso J, Val-Laillet D, Serduc R. Locomotion and eating behavior changes in Yucatan minipigs after unilateral radio-induced ablation of the caudate nucleus. Sci Rep. 2019 Nov 19;9(1):17082. doi: 10.1038/s41598-019-53518-2. PMID: 31745153.

Publikationen 2018

Schültke E, Bräuer-Krisch E, Blattmann H, Requardt H, Laissue JA, Hildebrandt G. Survival of rats bearing advanced intracerebral F 98 tumors after glutathione depletion and microbeam radiation therapy: conclusions from a pilot project. Radiat Oncol. 2018 May 10;13(1):89. doi: 10.1186/s13014-018-1038-6. PMID:29747666.

Smith R, Wang J, Seymour C, Fernandez-Palomo C, Fazzari J, Schültke E, Bräuer-Krisch E, Laissue J, Schroll C, Mothersill C. Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats. Dose Response. 2018 Jan 22;16(1):1559325817750068. doi: 10.1177/1559325817750068. eCollection 2018 Jan-Mar. PMID:29383012.

Publikationen 2017 und früher

Schültke E, Balosso J, Breslin T, Cavaletti G, Djonov V, Esteve F, Grotzer M, Hildebrandt G, Valdman A, Laissue J. Microbeam radiation therapy - grid therapy and beyond: a clinical perspective. Br J Radiol. 2017 Oct;90(1078):20170073. doi: 10.1259/bjr.20170073. Epub 2017 Jul 27. Review. PMID:28749174.

Fernandez-Palomo C, Schültke E, Bräuer-Krisch E, Laissue JA, Blattmann H, Seymour C, Mothersill C. Investigation of Abscopal and Bystander Effects in Immunocompromised Mice After Exposure to Pencilbeam and Microbeam Synchrotron Radiation. Health Phys. 2016 Aug;111(2):149-59. doi: 10.1097/HP.0000000000000525. PMID:27356059.

Grotzer MA, Schültke E, Bräuer-Krisch E, Laissue JA. Microbeam radiation therapy: Clinical perspectives. Phys Med. 2015 Sep;31(6):564-7. doi: 10.1016/j.ejmp.2015.02.011. Epub 2015 Mar 13. Review. PMID:25773883.

Bravin A, Olko P, Schültke E, Wilkens JJ. SYRA3 COST Action--Microbeam radiation therapy: Roots and prospects. Phys Med. 2015 Sep;31(6):561-3. doi: 10.1016/j.ejmp.2015.06.002. Epub 2015 Jun 27. PMID:26123367.

Fernandez-Palomo C, Bräuer-Krisch E, Laissue J, Vukmirovic D, Blattmann H, Seymour C, Schültke E, Mothersill C. Use of synchrotron medical microbeam irradiation to investigate radiation-induced bystander and abscopal effects in vivo. Phys Med. 2015 Sep;31(6):584-95. doi: 10.1016/j.ejmp.2015.03.004. Epub 2015 Mar 25. PMID:25817634.

Fernandez-Palomo C, Mothersill C, Bräuer-Krisch E, Laissue J, Seymour C, Schültke E. γ-H2AX as a marker for dose deposition in the brain of wistar rats after synchrotron microbeam radiation. PLoS One. 2015 Mar 23;10(3):e0119924. doi: 10.1371/journal.pone.0119924. eCollection 2015. PMID:2579942.

Mothersill C, Fernandez-Palomo C, Fazzari J, Smith R, Schültke E, Bräuer-Krisch E, Laissue A, Schroll C, Seymour C: Transmission of signals from rats receiving high doses of microbeam radiotherapy to cage mates: an inter-mammal bystander effect. Dose Response 2013 Aug 27;12(1):72-92. doi: 10.2203/dose-response.13-011.Mothersill. eCollection 2014 Jan. PMID:24659934.

Fernandez-Palomo C, Bräuer-Krisch E, Trippel M, Schroll C, Requardt H, Bartzsch S, Nikkhah G, Schültke E. DNA double strand breaks in the acute phase after synchrotron pencilbeam irradiation. JINST.

Schültke E, Trippel M, Bräuer-Krisch E, Renier M, Bartzsch S, Requardt H, Döbrössy, MD, Nikkhah G. Pencilbeam irradiation technique for whole brain radiotherapy: Technical and biological challenges in a small animal model. PLoS One. 2013; 89(6): 445-53. Epub 2013 Jan 28. PMID: 23383014.

Fernandez-Palomo C, Schültke E, Smith R, Bräuer-Krisch E, Laissue J, Schroll C, Fazzari J, Seymour C, Carmel Mothersill C. Bystander effects in tumor-free and tumor-bearing rat brains following irradiation by synchrotron X-rays. Int J Radiat Biol. 2013 Feb 26. [Epub ahead of print] PMID: 23363251.

Smith RW, Wang J, Schültke E, Seymour CB, Bräuer-Krisch E, Laissue JA, Blattmann H, Mothersill CE. Proteomic changes in the rat brain induced by homogenous irradiation and by the bystander effect resulting from high energy synchrotron X-ray microbeams. Int J Radiat Biol. 2013, 89(2):118-27. doi: 10.3109/09553002.2013.732252. Epub 2012 Oct 23. PMID: 23004567.

Schültke E, Juurlink B, Ataelmannan K, Laissue J, Blattmann H, Bräuer-Krisch E, Bravin A, Minczewska J, Crosbie J, Taherian H, Wysokinsky T, Chapman D, Griebel R, Fourney D. Memory and Survival after Microbeam Radiation Therapy. EJR 2008, 68(3 Suppl): 142-6.